期刊
SCIENCE
卷 345, 期 6197, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1255215
关键词
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资金
- FEBS Fellowship
- Marie Curie Fellowship [IEF-2009-252503]
- Netherlands Organization for Scientific Research (NWO) [ALW-VIDI-864.06.012, ALW-820.02.019]
- ERA-CAPS project EURO-PEC [849.13.006]
- European Research Council (Starting Grant CELLPATTERN) [281573]
- European Union 7th framework project [305564]
- Ministry of Education, Youth, and Sports of the Czech Republic [LK21306, LO1204]
- grant agency of the Czech Republic [14-34792S]
- NSF [IOS 1257111]
- European Research Council (ERC) [281573] Funding Source: European Research Council (ERC)
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1257111] Funding Source: National Science Foundation
- Austrian Science Fund (FWF) [I 1476] Funding Source: researchfish
Coordination of cell division and pattern formation is central to tissue and organ development, particularly in plants where walls prevent cell migration. Auxin and cytokinin are both critical for division and patterning, but it is unknown how these hormones converge upon tissue development. We identify a genetic network that reinforces an early embryonic bias in auxin distribution to create a local, nonresponding cytokinin source within the root vascular tissue. Experimental and theoretical evidence shows that these cells act as a tissue organizer by positioning the domain of oriented cell divisions. We further demonstrate that the auxin-cytokinin interaction acts as a spatial incoherent feed-forward loop, which is essential to generate distinct hormonal response zones, thus establishing a stable pattern within a growing vascular tissue.
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