期刊
SCIENCE
卷 344, 期 6188, 页码 1168-1173出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1252806
关键词
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资金
- one 973 Program [2013CB835200]
- one CAS Program [XDB13000000]
- BGI-Shenzhen [ZYC200903240077A, ZYC200903240078A]
- Inner Mongolia Agricultural University [30960246, 31260538]
- Roslin Institute
- University of Edinburgh and Biotechnology
- Biological Sciences Research Council, UK (BBSRC) [BB/1025360/1, BB/I025328/1]
- Institute Strategic Programme
- National Capability Grants
- Roslin Foundation
- Scottish Government, UK
- Department for Environment, Food and Rural Affairs/Higher Education Funding Council/Scottish Higher Education Funding Council Veterinary Training and Research Initiative, UK
- USDA-ARS, USA
- USDA-National Research Initiative Competitive Grants Program, USA [2008-03923, 2009-03305]
- Wellcome Trust [WT095908, WT098051]
- BBSRC [BB/I025506/1, BB/I025360/1]
- European Molecular Biology Laboratory
- USDA-NRSP-8, USA
- USDA-ARS [5348-32000-031-00D]
- Meat and Livestock Australia
- Australian Wool Innovation Limited through SheepGENOMICS, Australia
- Australian Government International Science Linkages Grant, Australia [CG090143]
- University of Sydney, Australia
- CSIRO, Australia
- AgResearch, NZ, Beef + Lamb NZ through Ovita, New Zealand
- INRA, France
- Agence Nationale de la Recherche project SheepSNPQTL, France
- European Union through the Seventh Framework Programme Quantomics project [KBBE222664]
- 3SR project [KBBE245140]
- Ole Romer grant from Danish Natural Science Research Council, BGI-Shenzhen, China
- Earmarked Fund for Modern China Wool & Cashmere Technology Research System [nycytx-40-3]
- Australian Department of Agriculture Food and Fisheries, Filling the Research Gap project, Host control of methane emissions
- Biotechnology and Biological Sciences Research Council [BB/I025328/1, BBS/E/D/20211552, BB/I025506/1, BBS/E/D/20310000, BB/I025360/1, BBS/E/D/20211550, BB/I025360/2, BBS/E/D/05191130] Funding Source: researchfish
- BBSRC [BB/I025506/1, BBS/E/D/20310000, BB/I025328/1, BBS/E/D/20211552, BBS/E/D/05191130, BB/I025360/2, BBS/E/D/20211550, BB/I025360/1] Funding Source: UKRI
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.
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