期刊
SCIENCE
卷 339, 期 6127, 页码 1593-1596出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1232993
关键词
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资金
- National Institute of General Medical Sciences [R01 GM103558-01]
- Merck
- Amgen
- Abbott
- Bristol-Myers Squibb
The direct beta-activation of saturated aldehydes and ketones has long been an elusive transformation. We found that photoredox catalysis in combination with organocatalysis can lead to the transient generation of 5 pi-electron beta-enaminyl radicals from ketones and aldehydes that rapidly couple with cyano-substituted aryl rings at the carbonyl beta-position. This mode of activation is suitable for a broad range of carbonyl beta-functionalization reactions and is amenable to enantioselective catalysis.
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