期刊
SCIENCE
卷 340, 期 6133, 页码 748-751出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1236192
关键词
-
资金
- NIH [R01AI080597, R21AI082141, R01AI061576]
- Foundation for the NIH through the Grand Challenges in Global Health Initiative of the Bill and Melinda Gates Foundation
Wolbachia is a maternally transmitted symbiotic bacterium of insects that has been proposed as a potential agent for the control of insect-transmitted diseases. One of the major limitations preventing the development of Wolbachia for malaria control has been the inability to establish inherited infections of Wolbachia in anopheline mosquitoes. Here, we report the establishment of a stable Wolbachia infection in an important malaria vector, Anopheles stephensi. In A. stephensi, Wolbachia strain wAlbB displays both perfect maternal transmission and the ability to induce high levels of cytoplasmic incompatibility. Seeding of naturally uninfected A. stephensi populations with infected females repeatedly resulted in Wolbachia invasion of laboratory mosquito populations. Furthermore, wAlbB conferred resistance in the mosquito to the human malaria parasite Plasmodium falciparum.
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