期刊
SCIENCE
卷 340, 期 6132, 页码 630-635出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1235454
关键词
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资金
- Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Immunotherapy of Cancer
- EU-FP7 SYBILLA [201106]
- BMBF ForSysPartner [0315267E]
- National Science Foundation [NSF PHY11-25915]
- [SFB TR 36 (TP-B10/13)]
- [SFB 1054 (TP-B09)]
- [SFB 914 (TP-B04)]
A core feature of protective T cell responses to infection is the robust expansion and diversification of naive antigen-specific T cell populations into short-lived effector and long-lived memory subsets. By means of in vivo fate mapping, we found a striking variability of immune responses derived from individual CD8(+) T cells and show that robust acute and recall immunity requires the initial recruitment of multiple precursors. Unbiased mathematical modeling identifies the random integration of multiple differentiation and division events as the driving force behind this variability. Within this probabilistic framework, cell fate is specified along a linear developmental path that progresses from slowly proliferating long-lived to rapidly expanding short-lived subsets. These data provide insights into how complex biological systems implement stochastic processes to guarantee robust outcomes.
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