期刊
SCIENCE
卷 342, 期 6164, 页码 1372-1375出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1240276
关键词
-
资金
- Deutsche Forschungsgemeinschaft [RO 4097/1-1]
- Damon Runyon Cancer Research Foundation
- NIH [RO1 HD047360]
In the process of morphological evolution, the extent to which cryptic, preexisting variation provides a substrate for natural selection has been controversial. We provide evidence that heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus. This variation is exposed by HSP90 inhibition and can be selected for, ultimately yielding a reduced-eye phenotype even in the presence of full HSP90 activity. Raising surface fish under conditions found in caves taxes the HSP90 system, unmasking the same phenotypic variation as does direct inhibition of HSP90. These results suggest that cryptic variation played a role in the evolution of eye loss in cavefish and provide the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据