期刊
SCIENCE
卷 341, 期 6146, 页码 660-664出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1237150
关键词
-
资金
- National Institutes of Health (NIH), NCI, Center for Cancer Research
- EMBO
Chromosome translocations are a hallmark of cancer cells. We have developed an experimental system to visualize the formation of translocations in living cells and apply it to characterize the spatial and dynamic properties of translocation formation. We demonstrate that translocations form within hours of the occurrence of double-strand breaks (DSBs) and that their formation is cell cycle-independent. Translocations form preferentially between prepositioned genome elements, and perturbation of key factors of the DNA repair machinery uncouples DSB pairing from translocation formation. These observations generate a spatiotemporal framework for the formation of translocations in living cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据