期刊
SCIENCE
卷 342, 期 6155, 页码 211-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1238016
关键词
-
资金
- New York University (NYU) Dean's Dissertation Award
- University of Cincinnati Postdoctoral Research Fellowship
- European Molecular Biology Organization (EMBO) long-term fellowships [ALTF 506-2002, ALTF 462-2008]
- NIH [RO1 EY13012, RO1-EY017907]
- Research to Prevent Blindness
Signaling pathways are reused for multiple purposes in plant and animal development. The Hippo pathway in mammals and Drosophila coordinates proliferation and apoptosis via the coactivator and oncoprotein YAP/Yorkie (Yki), which is homeostatically regulated through negative feedback. In the Drosophila eye, cross-repression between the Hippo pathway kinase LATS/Warts (Wts) and growth regulator Melted generates mutually exclusive photoreceptor subtypes. Here, we show that this all-or-nothing neuronal differentiation results from Hippo pathway positive feedback: Yki both represses its negative regulator, warts, and promotes its positive regulator, melted. This postmitotic Hippo network behavior relies on a tissue-restricted transcription factor network-including a conserved Otx/Orthodenticle-Nri/Traffic Jam feedforward module-that allows Warts-Yki-Melted to operate as a bistable switch. Altering feedback architecture provides an efficient mechanism to co-opt conserved signaling networks for diverse purposes in development and evolution.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据