期刊
SCIENCE
卷 337, 期 6095, 页码 738-742出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1217815
关键词
-
资金
- U.S. Department of Defense [BC074986]
- Novartis Pharmaceuticals
- Boston Scientific
- Wyss Institute for Biologically Inspired Engineering at Harvard University
- Wyss Technology Development Fellowship
Obstruction of critical blood vessels due to thrombosis or embolism is a leading cause of death worldwide. Here, we describe a biomimetic strategy that uses high shear stress caused by vascular narrowing as a targeting mechanism-in the same way platelets do-to deliver drugs to obstructed blood vessels. Microscale aggregates of nanoparticles were fabricated to break up into nanoscale components when exposed to abnormally high fluid shear stress. When coated with tissue plasminogen activator and administered intravenously in mice, these shear-activated nanotherapeutics induce rapid clot dissolution in a mesenteric injury model, restore normal flow dynamics, and increase survival in an otherwise fatal mouse pulmonary embolism model. This biophysical strategy for drug targeting, which lowers required doses and minimizes side effects while maximizing drug efficacy, offers a potential new approach for treatment of life-threatening diseases that result from acute vascular occlusion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据