期刊
SCIENCE
卷 335, 期 6072, 页码 1103-1106出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1206848
关键词
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资金
- European Commission [LSHG-CT-2006-037469]
- German Federal Ministry of Education and Research [0313978B]
- Department of Education, Science and Training [CG110055]
- National Health and Medical Research Council [455646]
Bacteria adapt to environmental stimuli by adjusting their transcriptomes in a complex manner, the full potential of which has yet to be established for any individual bacterial species. Here, we report the transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature. We comprehensively mapped transcription units (TUs) and grouped 2935 promoters into regulons controlled by various RNA polymerase sigma factors, accounting for similar to 66% of the observed variance in transcriptional activity. This global classification of promoters and detailed description of TUs revealed that a large proportion of the detected antisense RNAs arose from potentially spurious transcription initiation by alternative sigma factors and from imperfect control of transcription termination.
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