期刊
SCIENCE
卷 338, 期 6110, 页码 1097-1100出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1224000
关键词
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资金
- National Institute of Mental Health [MH069374, MH081162]
- National Institute of Neurological Disorders and Stroke [NS059312]
- Swiss National Science Foundation
Lateral prefrontal and posterior parietal cortical areas exhibit task-dependent activation during working memory tasks in humans and monkeys. Neurons in these regions become synchronized during attention-demanding tasks, but the contribution of these interactions to working memory is largely unknown. Using simultaneous recordings of neural activity from multiple areas in both regions, we find widespread, task-dependent, and content-specific synchronization of activity across the fronto-parietal network during visual working memory. The patterns of synchronization are prevalent among stimulus-selective neurons and are governed by influences arising in parietal cortex. These results indicate that short-term memories are represented by large-scale patterns of synchronized activity across the fronto-parietal network.
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