期刊
SCIENCE
卷 335, 期 6075, 页码 1510-1513出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1207615
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资金
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- Fondation pour la Recherche sur le Cerveau
- Conseil Regional d'Aquitaine
- Ministere de l'Enseignement superieur et de la Recherche
- University of Bordeaux
Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an altered pattern of neural activation in the hippocampal-amygdalar circuit. Mice become unable to identify the context as the correct predictor of the threat and show fear responses to a discrete cue not predicting the threat in normal conditions. These data demonstrate PTSD-like memory impairments in rodents and identify a potential pathophysiological mechanism of this condition.
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