期刊
SCIENCE
卷 338, 期 6107, 页码 647-651出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1226458
关键词
-
资金
- National Science Foundation
- Gordon and Betty Moore Foundation
Carbon-nitrogen (C-N) bond-forming reactions of amines with aryl halides to generate arylamines (anilines), mediated by a stoichiometric copper reagent at elevated temperature (>180 degrees C), were first described by Ullmann in 1903. In the intervening century, this and related C-N bond-forming processes have emerged as powerful tools for organic synthesis. Here, we report that Ullmann C-N coupling can be photoinduced by using a stoichiometric or a catalytic amount of copper, which enables the reaction to proceed under unusually mild conditions (room temperature or even -40 degrees C). An array of data are consistent with a single-electron transfer mechanism, representing the most substantial experimental support to date for the viability of this pathway for Ullmann C-N couplings.
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