期刊
SCIENCE
卷 337, 期 6098, 页码 1115-1119出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1225152
关键词
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资金
- Division of Intramural Research of the National Institute of Allergy and Infectious Diseases (NIAID)
- National Human Genome Research Institute, the National Cancer Institute, NIH [F30 DK094708]
- Human Frontier Science Program
Intestinal commensal bacteria induce protective and regulatory responses that maintain host-microbial mutualism. However, the contribution of tissue-resident commensals to immunity and inflammation at other barrier sites has not been addressed. We found that in mice, the skin microbiota have an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte function. Protective immunity to a cutaneous pathogen was found to be critically dependent on the skin microbiota but not the gut microbiota. Furthermore, skin commensals tuned the function of local T cells in a manner dependent on signaling downstream of the interleukin-1 receptor. These findings underscore the importance of the microbiota as a distinctive feature of tissue compartmentalization, and provide insight into mechanisms of immune system regulation by resident commensal niches in health and disease.
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