期刊
SCIENCE
卷 337, 期 6101, 页码 1536-1541出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1220893
关键词
-
资金
- Wild Cat Education and Conservation Fund
- HudsonAlpha Institute for Biotechnology
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
- federal funds [N01-CO-12400]
- Genentech
- National Institutes of Health
Color markings among felid species display both a remarkable diversity and a common underlying periodicity. A similar range of patterns in domestic cats suggests a conserved mechanism whose appearance can be altered by selection. We identified the gene responsible for tabby pattern variation in domestic cats as Transmembrane aminopeptidase Q (Taqpep), which encodes a membrane-bound metalloprotease. Analyzing 31 other felid species, we identified Taqpep as the cause of the rare king cheetah phenotype, in which spots coalesce into blotches and stripes. Histologic, genomic expression, and transgenic mouse studies indicate that paracrine expression of Endothelin3 (Edn3) coordinates localized color differences. We propose a two-stage model in which Taqpep helps to establish a periodic pre-pattern during skin development that is later implemented by differential expression of Edn3.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据