期刊
SCIENCE
卷 336, 期 6080, 页码 485-489出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1217718
关键词
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资金
- RIKEN
- Special Postdoctoral Researchers Program
- Grants-in-Aid for Scientific Research [19059003] Funding Source: KAKEN
Immunoglobulin A (IgA) is essential to maintain the symbiotic balance between gut bacterial communities and the host immune system. Here we provide evidence that the inhibitory co-receptor programmed cell death-1 (PD-1) regulates the gut microbiota through appropriate selection of IgA plasma cell repertoires. PD-1 deficiency generates an excess number of T follicular helper (T-FH) cells with altered phenotypes, which results in dysregulated selection of IgA precursor cells in the germinal center of Peyer's patches. Consequently, the IgAs produced in PD-1-deficient mice have reduced bacteria-binding capacity, which causes alterations of microbial communities in the gut. Thus, PD-1 plays a critical role in regulation of antibody diversification required for the maintenance of intact mucosal barrier.
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