期刊
SCIENCE
卷 338, 期 6112, 页码 1337-1340出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1228734
关键词
-
资金
- Novartis Institutes for Biomedical Research
- Career Award at the Scientific Interface from the Burroughs Welcome Fund
Despite more than 30 years of work on the Wnt signaling pathway, the basic mechanism of how the extracellular Wnt signal increases the intracellular concentration of beta-catenin is still contentious. Circumventing much of the detailed biochemistry, we used basic principles of chemical kinetics coupled with quantitative measurements to define the reactions on beta-catenin directly affected by the Wnt signal. We conclude that the core signal transduction mechanism is relatively simple, with only two regulated phosphorylation steps. Their partial inhibition gives rise to the full dynamics of the response and subsequently maintains a steady state in which the concentration of beta-catenin is increased.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据