期刊
SCIENCE
卷 338, 期 6108, 页码 807-810出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1224951
关键词
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资金
- Cooperative Research Centre for National Plant Biosecurity [CRC20080, CRC50150]
- Australian Research Council (ARC) [DP0558507]
- Grains Research and Development Corporation [UQ00010]
- National Institutes of Health [R01NS060129]
- National Health and Medical Research Council [569500]
- ARC Future Fellowship
- Queensland Smart State Fellowship
- Australian Postgraduate Award scholarships
- University of Queensland Research Scholarship
- AusAid scholarship
- NIH National Center for Research Resources
- Australian Research Council [DP0558507] Funding Source: Australian Research Council
Phosphine is a small redox-active gas that is used to protect global grain reserves, which are threatened by the emergence of phosphine resistance in pest insects. We find that polymorphisms responsible for genetic resistance cluster around the redox-active catalytic disulfide or the dimerization interface of dihydrolipoamide dehydrogenase (DLD) in insects (Rhyzopertha dominica and Tribolium castaneum) and nematodes (Caenorhabditis elegans). DLD is a core metabolic enzyme representing a new class of resistance factor for a redox-active metabolic toxin. It participates in four key steps of core metabolism, and metabolite profiles indicate that phosphine exposure in mutant and wild-type animals affects these steps differently. Mutation of DLD in C. elegans increases arsenite sensitivity. This specific vulnerability may be exploited to control phosphine-resistant insects and safeguard food security.
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