期刊
SCIENCE
卷 337, 期 6095, 页码 749-753出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1221140
关键词
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资金
- Max-Planck Society (INSERM-AMIGO)
- Deutsche Forschungsgemeinschaft (DFG)-Research Center Molecular Physiology of the Brain
- DFG-SPP [1172]
- DFG-Transregio [TRR43]
- European Union (EU) [FP7-202167 NeuroGLIA, FP7-ITN-237956 EdU-Glia]
- Research Initiative in Membrane Biology University of Kaiserslautern
- Dutch Organization for Medical Sciences
- Life Sciences
- Fund for Economic Structure Reinforcement (NeuroBasic)
- Prinses Beatrix Fonds
- EU ERCadvanced, CEREBNET program
- EU C7 program
- [DFG-SFB870]
- [DFG-SFB894]
- [R01-DC006881]
The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial (BG) cells express alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) composed exclusively of GluA1 and/or GluA4 subunits. With the use of conditional gene inactivation, we found that the majority of cerebellar GluA1/A4-type AMPARs are expressed in BG cells. In young mice, deletion of BG AMPARs resulted in retraction of glial appendages from Purkinje cell (PC) synapses, increased amplitude and duration of evoked PC currents, and a delayed formation of glutamatergic synapses. In adult mice, AMPAR inactivation also caused retraction of glial processes. The physiological and structural changes were accompanied by behavioral impairments in fine motor coordination. Thus, BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life.
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