期刊
SCIENCE
卷 336, 期 6086, 页码 1317-1321出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1220030
关键词
-
资金
- NIH, National Cancer Institute [P30CA016087]
- NIH [RO1AI062980]
- American Cancer Society [RSG-10-158-01-LIB]
The chemokine-mediated recruitment of effector T cells to sites of inflammation is a central feature of the immune response. The extent to which chemokine expression levels are limited by the intrinsic developmental characteristics of a tissue has remained unexplored. We show in mice that effector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating the fetus and placenta. Impaired accumulation was in part attributable to the epigenetic silencing of key T cell-attracting inflammatory chemokine genes in decidual stromal cells, as evidenced by promoter accrual of repressive histone marks. These findings give insight into mechanisms of fetomaternal immune tolerance, as well as reveal the epigenetic modification of tissue stromal cells as a modality for limiting effector T cell trafficking.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据