期刊
SCIENCE
卷 335, 期 6074, 页码 1348-1351出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1218094
关键词
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资金
- Deutsche Forschungsgemeinschaft [AL892/1-4, Graduiertenkolleg 1305]
- Higher Education Commission of Pakistan
- Netherlands Organization for Scientific Research [865.06.002, 834.08.001]
- Centre for BioSystems Genomics, Netherlands Genomics Initiative/Netherlands Organization for Scientific Research
Strigolactones, phytohormones with diverse signaling activities, have a common structure consisting of two lactones connected by an enol-ether bridge. Strigolactones derive from carotenoids via a pathway involving the carotenoid cleavage dioxygenases 7 and 8 (CCD7 and CCD8) and the iron-binding protein D27. We show that D27 is a beta-carotene isomerase that converts all-trans-beta-carotene into 9-cis-beta-carotene, which is cleaved by CCD7 into a 9-cis-configured aldehyde. CCD8 incorporates three oxygens into 9-cis-beta-apo-10'-carotenal and performs molecular rearrangement, linking carotenoids with strigolactones and producing carlactone, a compound with strigolactone-like biological activities. Knowledge of the structure of carlactone will be crucial for understanding the biology of strigolactones and may have applications in combating parasitic weeds.
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