期刊
SCIENCE
卷 337, 期 6091, 页码 243-245出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1219664
关键词
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资金
- Cancer Research UK
- European Research Council
- Royal Society
- Federation of European Biochemical Societies
- Human Frontier Science Program
- Cancer Research UK [11581] Funding Source: researchfish
The function of many DNA metabolism proteins depends on their ability to coordinate an iron-sulfur (Fe-S) cluster. Biogenesis of Fe-S proteins is a multistep process that takes place in mitochondria and the cytoplasm, but how it is linked to nuclear Fe-S proteins is not known. Here, we demonstrate that MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1, and MIP18. Cytoplasmic MMS19 also binds to multiple nuclear Fe-S proteins involved in DNA metabolism. In the absence of MMS19, a failure to transfer Fe-S clusters to target proteins is associated with Fe-S protein instability and preimplantation death of mice in which Mms19 has been knocked out. We propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair.
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