期刊
SCIENCE
卷 337, 期 6094, 页码 584-587出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1221881
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资金
- European Community
- UK Biotechnology and Biological Sciences Research Council (BBSRC)
- European Research Council
- BBSRC [BBS/E/J/000CA369, BBS/E/J/000CA344, BB/E009662/1, BBS/E/J/000CA355] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E009662/1, BBS/E/J/000CA355, BBS/E/J/000CA369, BBS/E/J/000CA344] Funding Source: researchfish
Arabidopsis thaliana accessions have adapted to growth in a wide range of climates. Variation in flowering and alignment of vernalization response with winter length are central to this adaptation. Vernalization involves the epigenetic silencing of the floral repressor FLC via a conserved Polycomb (PRC2) mechanism involving trimethylation of Lys(27) on histone H3 (H3K27me3). We found that variation for response to winter length maps to cis polymorphism within FLC. A rare combination of four polymorphisms localized around the nucleation region of a PHD-Polycomb complex determines a need for longer cold. Chromatin immunoprecipitation experiments indicate that these polymorphisms influence the accumulation of H3K27me3 in Arabidopsis accession Lov-1, both at the nucleation site and over the gene body. Quantitative modulation of chromatin silencing through cis variation may be a general mechanism contributing to evolutionary change.
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