期刊
SCIENCE
卷 334, 期 6054, 页码 369-373出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1212959
关键词
-
资金
- NIH [F32-HG004830]
- NSF [DGE-0504645, MCB-0929402, MCB1122246]
- European Union [252475]
- NIH/National Center for Research Resources [UL1 RR025774]
- Mary K. Chapman Foundation
- Howard Hughes Medical Institute
- Gordon and Betty Moore Foundation (GBMF)
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0929402] Funding Source: National Science Foundation
Epigenetic information, which may affect an organism's phenotype, can be stored and stably inherited in the form of cytosine DNA methylation. Changes in DNA methylation can produce meiotically stable epialleles that affect transcription and morphology, but the rates of spontaneous gain or loss of DNA methylation are unknown. We examined spontaneously occurring variation in DNA methylation in Arabidopsis thaliana plants propagated by single-seed descent for 30 generations. We identified 114,287 CG single methylation polymorphisms and 2485 CG differentially methylated regions (DMRs), both of which show patterns of divergence compared with the ancestral state. Thus, transgenerational epigenetic variation in DNA methylation may generate new allelic states that alter transcription, providing a mechanism for phenotypic diversity in the absence of genetic mutation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据