期刊
SCIENCE
卷 332, 期 6027, 页码 342-346出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1202998
关键词
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资金
- Office of Naval Research
- Army Research Office
- National Science Foundation
- Department of Energy
- National Institutes of Health
- Sloan Research Foundation
- Arizona State University
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0001016]
We present a strategy to design and construct self-assembling DNA nanostructures that define intricate curved surfaces in three-dimensional (3D) space using the DNA origami folding technique. Double-helical DNA is bent to follow the rounded contours of the target object, and potential strand crossovers are subsequently identified. Concentric rings of DNA are used to generate in-plane curvature, constrained to 2D by rationally designed geometries and crossover networks. Out-of-plane curvature is introduced by adjusting the particular position and pattern of crossovers between adjacent DNA double helices, whose conformation often deviates from the natural, B-form twist density. A series of DNA nanostructures with high curvature-such as 2D arrangements of concentric rings and 3D spherical shells, ellipsoidal shells, and a nanoflask-were assembled.
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