期刊
SCIENCE
卷 335, 期 6064, 页码 100-104出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1216166
关键词
-
资金
- National Institute of Health [1DP20D001378]
- Doris Duke Charitable Foundation [2010054]
- United States Army Medical Research Acquisition Activity [W81XWH-10-2-0161]
- National Institute of Biomedical Imaging and Bioengineering [P41 EB002503]
- Massachusetts General Hospital Executive Committee on Research
Cells use both deterministic and stochastic mechanisms to generate cell-to-cell heterogeneity, which enables the population to better withstand environmental stress. Here we show that, within a clonal population of mycobacteria, there is deterministic heterogeneity in elongation rate that arises because mycobacteria grow in an unusual, unipolar fashion. Division of the asymmetrically growing mother cell gives rise to daughter cells that differ in elongation rate and size. Because the mycobacterial cell division cycle is governed by time, not cell size, rapidly elongating cells do not divide more frequently than slowly elongating cells. The physiologically distinct subpopulations of cells that arise through asymmetric growth and division are differentially susceptible to clinically important classes of antibiotics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据