期刊
SCIENCE
卷 332, 期 6030, 页码 732-735出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1198851
关键词
-
资金
- ICREA Academia (Generalitat de Catalunya)
- Fundacion Marcelino Botin (FMB)
- Ministerio de Ciencia y Innovacion [BFU2008-00530, BIO2009-07762]
- Swiss National Science Foundation
- ETHZ
- [155111]
Mitogen-activated protein kinase (MAPK) cascades are conserved signaling modules that control many cellular processes by integrating intra- and extracellular cues. The p38/Hog1 MAPK is transiently activated in response to osmotic stress, leading to rapid translocation into the nucleus and induction of a specific transcriptional program. When investigating the dynamic interplay between Hog1 activation and Hog1-driven gene expression, we found that Hog1 activation increases linearly with stimulus, whereas the transcriptional output is bimodal. Modeling predictions, corroborated by single-cell experiments, established that a slow stochastic transition from a repressed to an activated transcriptional state in conjunction with transient Hog1 activation generates this behavior. Together, these findings provide a molecular mechanism by which a cell can impose a transcriptional threshold in response to a linear signaling behavior.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据