期刊
SCIENCE
卷 333, 期 6042, 页码 596-601出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1203659
关键词
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资金
- NIH [GM-066025, P50-HG004233]
- NSF [2010 0929410, 0703905, 0520253, 0313578, 0726408]
- U.S. Department of Energy (DOE) [FG02-95ER20187]
- U.K. Biotechnology and Biological Sciences Research Council [E024815, F005806, G015066]
- European Commission [LSHG-CT-2006-037704]
- European Research Area in Plant Genomics
- Biotechnology and Biological Sciences Research Council [BB/G015066/1, BB/E024815/1] Funding Source: researchfish
- BBSRC [BB/E024815/1, BB/G015066/1] Funding Source: UKRI
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0703905] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0313578] Funding Source: National Science Foundation
- Div Of Biological Infrastructure
- Direct For Biological Sciences [0726408, 0520253] Funding Source: National Science Foundation
Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and similar to 8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.
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