期刊
SCIENCE
卷 334, 期 6059, 页码 1144-1147出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1211878
关键词
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资金
- NIH National Center for Research Resources
- NIH [GM065444-03]
- Centre National de la Recherche Scientifique
- Univ. of Pierre and Marie Curie
- Agence Nationale de la Recherche [ANR 07-BLAN-0063-21]
- Association pour la Recherche contre le Cancer
- Agence Nationale de la Recherche (ANR) [ANR-07-BLAN-0063] Funding Source: Agence Nationale de la Recherche (ANR)
In sexual reproduction of most animals, the spermatozoon provides DNA and centrioles, together with some cytoplasm and organelles, to the oocyte that is being fertilized. Paternal mitochondria and their genomes are generally eliminated in the embryo by an unknown degradation mechanism. We show that, upon fertilization, a Caenorhabditis elegans spermatozoon triggers the recruitment of autophagosomes within minutes and subsequent paternal mitochondria degradation. Whereas the nematode-specific sperm membranous organelles are ubiquitinated before autophagosome formation, the mitochondria are not. The degradation of both paternal structures and mitochondrial DNA requires an LC3-dependent autophagy. Analysis of fertilized mouse embryos shows the localization of autophagy markers, which suggests that this autophagy event is evolutionarily conserved to prevent both the transmission of paternal mitochondrial DNA to the offspring and the establishment of heteroplasmy.
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