期刊
SCIENCE
卷 331, 期 6024, 页码 1621-1624出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1198363
关键词
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资金
- Howard Hughes Medical Institute
- NIH [DK67158, DK62434, DK40936, U24 DK076169]
- Robert A. Welch Foundation [I-1275, I-558]
- Yale and Case Western Reserve University Mouse Metabolic Phenotyping Centers
Fibroblast growth factor (FGF) 19 is an enterokine synthesized and released when bile acids are taken up into the ileum. We show that FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity. Mice lacking FGF15 (the mouse FGF19 ortholog) fail to properly maintain blood concentrations of glucose and normal postprandial amounts of liver glycogen. FGF19 treatment restored the loss of glycogen in diabetic animals lacking insulin. Thus, FGF19 activates a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.
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