期刊
SCIENCE
卷 331, 期 6023, 页码 1443-1447出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1199967
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [19002010, 18700378]
- Takeda Science Foundation
- Japan Society for the Promotion of Science (JSPS) [1811234, 211438]
- Grants-in-Aid for Scientific Research [19002010, 18700378] Funding Source: KAKEN
The primate temporal cortex implements visual long-term memory. However, how its interlaminar circuitry executes cognitive computations is poorly understood. Using linear-array multicontact electrodes, we simultaneously recorded unit activities across cortical layers in the perirhinal cortex of macaques performing a pair-association memory task. Cortical layers were estimated on the basis of current source density profiles with histological verifications, and the interlaminar signal flow was determined with cross-correlation analysis between spike trains. During the cue period, canonical feed-forward signals flowed from granular to supragranular layers and from supragranular to infragranular layers. During the delay period, however, the signal flow reversed to the feed-back direction: from infragranular to supragranular layers. This reversal of signal flow highlights how the temporal cortex differentially recruits its laminar circuits for sensory and mnemonic processing.
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