期刊
SCIENCE
卷 332, 期 6029, 页码 586-589出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1201647
关键词
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资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [RO1-AR42177, AR60306, AR47364]
- UK Engineering and Physical Sciences Research Council
- Royal Society
- California Institute for Regenerative Medicine
- [RO1-AR47709]
Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs.
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