期刊
SCIENCE
卷 334, 期 6054, 页码 385-389出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1207403
关键词
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资金
- Agence Nationale de la Recherche (ANR) [07-JCJC-0108-01, ANR-09-EMER-005-02]
- Action Concertee Incitative (ACI) [NIC0027]
Spatial representation is an active process that requires complex multimodal integration from a large interacting network of cortical and subcortical structures. We sought to determine the role of cerebellar protein kinase C (PKC)-dependent plasticity in spatial navigation by recording the activity of hippocampal place cells in transgenic L7PKCI mice with selective disruption of PKC-dependent plasticity at parallel fiber-Purkinje cell synapses. Place cell properties were exclusively impaired when L7PKCI mice had to rely on self-motion cues. The behavioral consequence of such a deficit is evidenced here by selectively impaired navigation capabilities during a path integration task. Together, these results suggest that cerebellar PKC-dependent mechanisms are involved in processing self-motion signals essential to the shaping of hippocampal spatial representation.
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