期刊
SCIENCE
卷 333, 期 6046, 页码 1141-1144出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1205727
关键词
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资金
- Vaadia-Binational Agricultural Research and Development [FI-413]
- Cold Spring Harbor Laboratory
- Rural Development Administration, Korea [PJ008109]
- NSF [1027003]
- Rural Development Administration (RDA), Republic of Korea [PJ00810920111139300] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0963400] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1027003] Funding Source: National Science Foundation
Cell-to-cell communication in plants includes the selective trafficking of transcription factors and other signals through plasmodesmata. The KNOTTED1 (KN1) homeobox (KNOX) family transcription factors, which use this pathway, are essential for stem cell establishment and/or maintenance. Here we show that KN1 trafficking requires the chaperonin complex, which belongs to a group of cytosolic chaperones that fold specific substrate proteins. Genetic and physical interaction data show a functional relevance for chaperonins in KNOX family-dependent stem cell maintenance. Furthermore, tissue-specific complementation assays indicate a mechanistic basis for chaperonin function during the posttranslocational refolding process. Our study shows that chaperonins are essential for the cell-to-cell trafficking of a subset of mobile transcription factors and demonstrates the importance of chaperonin-dependent protein trafficking for plant stem cell function.
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