期刊
SCIENCE
卷 334, 期 6061, 页码 1420-1424出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1213214
关键词
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资金
- American Heart Association [AHA 0825548D]
- NIH [R01 HL071546, U01 HL100405]
- Spain fund for Regenerative Medicine
- W. W. Smith Endowed Chair
Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct from +4 cells, and the relationship between them is unknown, though both give rise to all intestinal epithelial lineages. We demonstrate that Hopx, an atypical homeobox protein, is a specific marker of +4 cells. Hopx-expressing cells give rise to CBCs and all mature intestinal epithelial lineages. Conversely, CBCs can give rise to +4 Hopx-positive cells. These findings demonstrate a bidirectional lineage relationship between active and quiescent stem cells in their niches.
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