期刊
SCIENCE
卷 331, 期 6019, 页码 924-928出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1196164
关键词
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资金
- CNRS, Fondation Simone et Cino del Duca
- Federation pour la Recherche sur le Cerveau
- Agence Nationale de la Recherche (ANR) [09-MNPS-005-01]
Although formation and stabilization of long-lasting associative memories are thought to require time-dependent coordinated hippocampal-cortical interactions, the underlying mechanisms remain unclear. Here, we present evidence that neurons in the rat cortex must undergo a tagging process upon encoding to ensure the progressive hippocampal-driven rewiring of cortical networks that support remote memory storage. This process was AMPA-and N-methyl-D-aspartate receptor-dependent, information-specific, and capable of modulating remote memory persistence by affecting the temporal dynamics of hippocampal-cortical interactions. Post-learning reinforcement of the tagging process via time-limited epigenetic modifications resulted in improved remote memory retrieval. Thus, early tagging of cortical networks is a crucial neurobiological process for remote memory formation whose functional properties fit the requirements imposed by the extended time scale of systems-level memory consolidation.
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