期刊
SCIENCE
卷 333, 期 6042, 页码 601-607出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1203877
关键词
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资金
- NSF [0703905, 0520253, 0313578, 0703908]
- National Human Genome Research Institute [R01HG001715]
- Canada Excellence Research Chairs Program
- Canadian Institute for Advanced Research Fellowship
- James S. McDonnell Foundation [220020084]
- Sixth Framework Programme [LSHG-CT-2006-037704]
- National Institute of General Medical Sciences [R01GM066025]
- U.S. Department of Agriculture, Agricultural Research Service [1907-21000-030]
- NIH [F32HG004098, F32HG004830]
- Biotechnology and Biological Sciences Research Council [F005806]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0703905] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0313578, 0520253] Funding Source: National Science Foundation
- Office Of The Director
- Office of Integrative Activities [1028394] Funding Source: National Science Foundation
Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.
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