期刊
SCIENCE
卷 329, 期 5991, 页码 562-565出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1191880
关键词
-
资金
- Japan Society for the Promotion of Science (JSPS) [21390534]
- NIH, NIDCR
- Grants-in-Aid for Scientific Research [21390534] Funding Source: KAKEN
During embryonic development, many organs form by extensive branching of epithelia through the formation of clefts and buds. In cleft formation, buds are delineated by the conversion of epithelial cell-cell adhesions to cell-matrix adhesions, but the mechanisms of cleft formation are not clear. We have identified Btbd7 as a dynamic regulator of branching morphogenesis. Btbd7 provides a mechanistic link between the extracellular matrix and cleft propagation through its highly focal expression leading to local regulation of Snail2 (Slug), E-cadherin, and epithelial cell motility. Inhibition experiments show that Btbd7 is required for branching of embryonic mammalian salivary glands and lungs. Hence, Btbd7 is a regulatory gene that promotes epithelial tissue remodeling and formation of branched organs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据