期刊
SCIENCE
卷 327, 期 5968, 页码 1000-1004出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1179689
关键词
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资金
- Chinese Ministry of Education
- state key development programs of basic research of China [2009CB918401, 2006CB806700]
- national high technology research and development program of China [2006AA02A308]
- Chinese National Science Foundation [30600112, 30871255]
- Shanghai key basic research projects [06JC14086, 07PJ14011, 08JC1400900]
- NIH [R01GM51586, R01CA108941, R01CA65572]
- MRC [MC_UP_A024_1008, MC_U105181009] Funding Source: UKRI
- Medical Research Council [MC_U105181009, MC_UP_A024_1008] Funding Source: researchfish
Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the modification of histones and nuclear transcription regulators. We show that lysine acetylation is a prevalent modification in enzymes that catalyze intermediate metabolism. Virtually every enzyme in glycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, the urea cycle, fatty acid metabolism, and glycogen metabolism was found to be acetylated in human liver tissue. The concentration of metabolic fuels, such as glucose, amino acids, and fatty acids, influenced the acetylation status of metabolic enzymes. Acetylation activated enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase in fatty acid oxidation and malate dehydrogenase in the TCA cycle, inhibited argininosuccinate lyase in the urea cycle, and destabilized phosphoenolpyruvate carboxykinase in gluconeogenesis. Our study reveals that acetylation plays a major role in metabolic regulation.
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