期刊
SCIENCE
卷 327, 期 5963, 页码 284-286出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1185068
关键词
-
资金
- Cancer Research UK Funding Source: Medline
Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I-like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.
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