期刊
SCIENCE
卷 328, 期 5985, 页码 1576-1580出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1188210
关键词
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资金
- European Commission
- Kavli Foundation
- Research Council of Norway
In the adult brain, space and orientation are represented by an elaborate hippocampal-parahippocampal circuit consisting of head-direction cells, place cells, and grid cells. We report that a rudimentary map of space is already present when 21/2-week-old rat pups explore an open environment outside the nest for the first time. Head-direction cells in the pre- and parasubiculum have adultlike properties from the beginning. Place and grid cells are also present but evolve more gradually. Grid cells show the slowest development. The gradual refinement of the spatial representation is accompanied by an increase in network synchrony among entorhinal stellate cells. The presence of adultlike directional signals at the onset of navigation raises the possibility that such signals are instrumental in setting up networks for place and grid representation.
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