期刊
SCIENCE
卷 327, 期 5963, 页码 328-331出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1182612
关键词
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资金
- Bill and Melinda Gates Foundation
- Medicines for Malaria Venture
- Garfield Weston Foundation for the Centre for Novel Agricultural Products
Artemisinin is a plant natural product produced by Artemisia annua and the active ingredient in the most effective treatment for malaria. Efforts to eradicate malaria are increasing demand for an affordable, high-quality, robust supply of artemisinin. We performed deep sequencing on the transcriptome of A. annua to identify genes and markers for fast-track breeding. Extensive genetic variation enabled us to build a detailed genetic map with nine linkage groups. Replicated field trials resulted in a quantitative trait loci (QTL) map that accounts for a significant amount of the variation in key traits controlling artemisinin yield. Enrichment for positive QTLs in parents of new high-yielding hybrids confirms that the knowledge and tools to convert A. annua into a robust crop are now available.
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