期刊
SCIENCE
卷 327, 期 5973, 页码 1644-1648出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1184008
关键词
-
资金
- Intramural Research Program of the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH
Extracellular matrices in diverse biological systems are cross-linked by dityrosine covalent bonds catalyzed by the peroxidase/oxidase system. We show that a peroxidase, secreted by the Anopheles gambiae midgut, and dual oxidase form a dityrosine network that decreases gut permeability to immune elicitors. This network protects the microbiota by preventing activation of epithelial immunity. It also provides a suitable environment for malaria parasites to develop within the midgut lumen without inducing nitric oxide synthase expression. Disruption of this barrier results in strong and effective pathogen-specific immune responses.
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