期刊
SCIENCE
卷 328, 期 5974, 页码 62-67出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1182868
关键词
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资金
- NICHD/NIH Contraceptive Development Research Centers [U54 HD4254]
- Uehara Memorial Foundation
- Naito Foundation
- Grants-in-Aid for Scientific Research [20116004] Funding Source: KAKEN
Stem cells support tissue maintenance by balancing self-renewal and differentiation. In mice, it is believed that a homogeneous stem cell population of single spermatogonia supports spermatogenesis, and that differentiation, which is accompanied by the formation of connected cells (cysts) of increasing length, is linear and nonreversible. We evaluated this model with the use of lineage analysis and live imaging, and found that this putative stem cell population is not homogeneous. Instead, the stem cell pool that supports steady-state spermatogenesis is contained within a subpopulation of single spermatogonia. We also found that cysts are not committed to differentiation and appear to recover stem cell potential by fragmentation, and that the fate of individual spermatogonial populations was markedly altered during regeneration after damage. Thus, there are multiple and reversible paths from stem cells to differentiation, and these may also occur in other systems.
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