期刊
SCIENCE
卷 330, 期 6001, 页码 197-U50出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1194238
关键词
-
资金
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1019626] Funding Source: National Science Foundation
Bacterial biofilms are structured multicellular communities involved in a broad range of infections. Knowing how free-swimming bacteria adapt their motility mechanisms near surfaces is crucial for understanding the transition between planktonic and biofilm phenotypes. By translating microscopy movies into searchable databases of bacterial behavior, we identified fundamental type IV pili-driven mechanisms for Pseudomonas aeruginosa surface motility involved in distinct foraging strategies. Bacteria stood upright and walked with trajectories optimized for two-dimensional surface exploration. Vertical orientation facilitated surface detachment and could influence biofilm morphology.
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