期刊
SCIENCE
卷 328, 期 5984, 页码 1391-1394出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1187703
关键词
-
资金
- UK Biotechnology and Biological Sciences Research Council
- Wellcome Trust [083620Z]
- University of Manchester
- UK Medical Research Council [G0601205]
- MRC [G0601205] Funding Source: UKRI
The inhabitants of the mammalian gut are not always relatively benign commensal bacteria but may also include larger and more parasitic organisms, such as worms and protozoa. At some level, all these organisms are capable of interacting with each other. We found that successful establishment of the chronically infecting parasitic nematode Trichuris muris in the large intestine of mice is dependent on microflora and coincident with modulation of the host immune response. By reducing the number of bacteria in the host animal, we significantly reduced the number of hatched T. muris eggs. Critical interactions between bacteria (microflora) and parasites (macrofauna) introduced a new dynamic to the intestinal niche, which has fundamental implications for our current concepts of intestinal homeostasis and regulation of immunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据