期刊
SCIENCE
卷 327, 期 5969, 页码 1145-1148出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1183962
关键词
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资金
- National Institutes of Health [R01 NS048528, P50 MH077972, EY016317]
- Dana Foundation [P0001351]
- Adelson Medical Research Foundation
- California Institute for Regenerative Medicine
- NIDCD [K99/R00]
Critical periods are times of pronounced brain plasticity. During a critical period in the postnatal development of the visual cortex, the occlusion of one eye triggers a rapid reorganization of neuronal responses, a process known as ocular dominance plasticity. We have shown that the transplantation of inhibitory neurons induces ocular dominance plasticity after the critical period. Transplanted inhibitory neurons receive excitatory synapses, make inhibitory synapses onto host cortical neurons, and promote plasticity when they reach a cellular age equivalent to that of endogenous inhibitory neurons during the normal critical period. These findings suggest that ocular dominance plasticity is regulated by the execution of a maturational program intrinsic to inhibitory neurons. By inducing plasticity, inhibitory neuron transplantation may facilitate brain repair.
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