期刊
SCIENCE
卷 330, 期 6010, 页码 1549-1551出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1195203
关键词
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资金
- U.S. NSF [EF-0412213, IOS-0744875, IOS-0924861, MCB-0639226]
- U.S. Department of Agriculture National Institute of Food and Agriculture [2004-35600-15055, 2007-35319-18100]
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/C509123/1, BB/E024815/1, BB/F0161901, T12144]
- Engineering and Physical Sciences Research Council/BBSRC [EP/F500025/1]
- Gatsby [GAT2545]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0924861] Funding Source: National Science Foundation
- Biotechnology and Biological Sciences Research Council [BB/E007120/1, BB/C509123/1, BB/E024882/1, BB/G015244/1, BB/E024815/1] Funding Source: researchfish
- BBSRC [BB/G015244/1, BB/E024882/1, BB/E007120/1, BB/E024815/1] Funding Source: UKRI
Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.
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