期刊
SCIENCE
卷 327, 期 5970, 页码 1254-1258出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1183112
关键词
-
资金
- Cancer Research UK
- Canadian Institute of Health Research
- Cancer Research UK [11582] Funding Source: researchfish
Meiotic crossovers (COs) are tightly regulated to ensure that COs on the same chromosome are distributed far apart ( crossover interference, COI) and that at least one CO is formed per homolog pair (CO homeostasis). CO formation is controlled in part during meiotic double-strand break (DSB) creation in Caenorhabditis elegans, but a second level of control must also exist because meiotic DSBs outnumber COs. We show that the anti-recombinase RTEL-1 is required to prevent excess meiotic COs, probably by promoting meiotic synthesis-dependent strand annealing. Two distinct classes of meiotic COs are increased in rtel-1 mutants, and COI and homeostasis are compromised. We propose that RTEL-1 implements the second level of CO control by promoting noncrossovers.
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