期刊
SCIENCE
卷 328, 期 5978, 页码 633-636出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1183670
关键词
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资金
- U.S. Department of Energy's Office of Science
- University of California, Lawrence Berkeley National Laboratory [DE-AC02-05CH11231]
- Lawrence Livermore National Laboratory [DE-AC52-07NA27344]
- Los Alamos National Laboratory [DE-AC02-06NA25396]
- NIH, National Library of Medicine
- National Human Genome Research Institute (NHGRI) [U01 HG02155]
- National Institute of Child Health and Human Development
- Medical Research Council [MC_U117560482] Funding Source: researchfish
- MRC [MC_U117560482] Funding Source: UKRI
The western clawed frog Xenopus tropicalis is an important model for vertebrate development that combines experimental advantages of the African clawed frog Xenopus laevis with more tractable genetics. Here we present a draft genome sequence assembly of X. tropicalis. This genome encodes more than 20,000 protein-coding genes, including orthologs of at least 1700 human disease genes. Over 1 million expressed sequence tags validated the annotation. More than one-third of the genome consists of transposable elements, with unusually prevalent DNA transposons. Like that of other tetrapods, the genome of X. tropicalis contains gene deserts enriched for conserved noncoding elements. The genome exhibits substantial shared synteny with human and chicken over major parts of large chromosomes, broken by lineage-specific chromosome fusions and fissions, mainly in the mammalian lineage.
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